This back test is a fairly decent representation of my portfolio of Biotech stocks I traded last year. Despite the thin volatility in the IBB and S&P 500, a select few small cap biotech companies had tremendous returns due to PDUFA's and FDA reviews of drug candidates. My strategy is technically incredibly risky, but I think that with proper analysis the risk becomes minute. Best of all, this strategy works with Large- cap stocks as well. The model isn't entirely accurate, however, because my strategy is based on trades and not year long investments, making returns slightly higher than represented here.