Initialize() is called only once upon first deploy both in backtesting and live trading. This function is used to setup your variables. In live trading, if your algorithm has a fetcher call, your file will be retrieved every day because we don't save a copy of your data.
Handle_data() is called once per market event. This means it will pull new data for your securities whenever it's available. For liquid stocks (APPL, SPY, etc) handle_data will get called every minute because there is trade data to be processed. These stocks trade every minute. For illiquid stocks, handle_data will get called less frequently, maybe once every couple of minutes, when there is new trade data for the securities.
If you are using illiquid stocks, but want to make sure handle_data gets called every minute (for whatever reason, perhaps your algorithm design), you can include SPY in your stock universe.
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